First raised at the order of Pope Liberius in the mid-fourth century, the Liberian basilica was rebuilt by Pope Sixtus III shortly after the Council of Ephesus affirmed Mary’s title as Mother of God in 431. Rededicated at that time to the Mother of God, St. Mary Major is the largest church in the world honoring God through Mary. Standing atop one of Rome’s seven hills, the Esquiline, it has survived many restorations without losing its character as an early Roman basilica. Its interior retains three naves divided by colonnades in the style of Constantine’s era. Fifth-century mosaics on its walls testify to its antiquity.
St. Mary Major is one of the four Roman basilicas known as patriarchal churches in memory of the first centers of the Church. St. John Lateran represents Rome, the See of Peter; St. Paul Outside the Walls, the See of Alexandria, allegedly the see presided over by Mark; St. Peter’s, the See of Constantinople; and St. Mary’s, the See of Antioch, where Mary is supposed to have spent most of her later life.